Breaking the Cycle of Mitochondrial Dysfunction

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Each cell in the body relies on mitochondria- not just for energy, but for metabolism, resilience, and longevity.

With chronic inflammation endlessly on the rise and countless sources of oxidative stress surrounding us, impaired mitochondrial function becomes equally prevalent. Between poor diets, sedentary lifestyles, and the widespread use of agents like statins, SSRIs, antibiotics, and Tylenol[1], mitochondrial damage is inevitable. 

Even those who do “everything right” aren’t immune—environmental toxins, heavy metals, mold, and chronic infections are nearly unavoidable. Perhaps you live in a city where industrial pollutants fill the air. Maybe you’re an avid hiker, taking in nature’s beauty while unintentionally increasing your risk of tick-borne infections. Or you may be living in a mold-ridden home without realizing it. Even strenuous exercise without adequate nutritional support and recovery incurs oxidative damage. 

The Vicious Cycle 

Excess oxidative stress damages mitochondrial membranes, making them “leaky”. This disrupts energy production, damages mitochondrial DNA, and weakens vital structures within the cell, setting the stage for broader health concerns. 

As mitochondrial health declines, inflammation rises—fueling a vicious cycle that underlies countless chronic diseases.

Let’s explore a few examples of physiological dysfunctions and imbalances linked to compromised mitochondrial health:

  • Neurological and cognitive: Damaged mitochondria lead to impaired ATP production, increased oxidative stress, and disrupted calcium handling, resulting in neuronal damage, cell death, and cognitive deficits. [2, 3, 4]
  • Cardiovascular: Less efficient ATP production, increased oxidative stress, and impaired calcium handling lead to endothelial dysfunction, cardiac remodeling, and cell death. [5]
  • Metabolic: Excessive nutrient intake overwhelms the Kreb’s cycle, amplifying oxidative stress and inflammation, and the cycle continues. This, in turn, can extend to even more severe pathologies including alterations in the blood-brain barrier and neuroinflammation. [6]
  • Neuropsychiatric: Impaired ATP production and oxidative stress contribute to alterations in the blood-brain barrier and neuroinflammatory pathways. [7]

So, what can we do about it? 

Breaking the Cycle of Leaky Mitochondria

Supporting mitochondrial health requires a multifaceted approach.  

From a holistic perspective, it requires first establishing the foundations of health: Proper nutrition, regular movement, restorative sleep, and consciously limiting toxin exposure. 

But sometimes, even the best efforts need extra support. This is where ATP360® and Tri-Fortify® come in. 

Synergistic Solutions: Peer-Reviewed & Published 

ATP 360® supports mitochondrial membrane repair, energy efficiency, and aids in glutathione recycling, ensuring lasting protection and optimal function. 

Tri-Fortify® provides clinically studied liposomal glutathione, helping to neutralize oxidative stress and protect mitochondrial membranes from damage. 

Together, they form a powerful foundation for cellular health. 

The ATP360® study (2021, Alternative Therapies) examined the impacts of the formulation on individuals experiencing persistent energy concerns.[8] 

  • 52% improvement in energy levels after 2 months (35% improvement after just 1 week)
  • 31% improvement in mental functioning
  • 19% reduction in TNF-alpha
  • 68% improvement in sleep
 

The reduction in inflammation, as evidenced by a significant decrease in TNF-alpha, may be linked, in part, to the tocotrienols. This may help to explain the observed improvements in mental function and sleep, as neuroinflammation significantly affects both. 

The Tri-Fortify® study (2017, European Journal of Clinical Nutrition) was conducted at Penn State College of Medicine and assessed the impact of two different doses of Tri-Fortify® on intracellular glutathione levels.[9] 

Both doses were effective, with results showing: 

  • 28% increase in intracellular glutathione levels at 2 weeks (23% increase after just 1 week)
  • 400% increase in natural killer cell function
  • 25% reduction in oxidative stress 

Together, these formulations create a comprehensive foundation for mitochondrial health—reducing inflammation, mitigating oxidative stress, optimizing energy, and protecting mitochondrial function at its core. 

Help Your Patients Reclaim Their Vitality 

Want to learn more? Contact your sales representative today for detailed clinical insights and personalized support to best serve your patients. 

References

1. Auxiliare Kuretu, Arineitwe C, Mamosheledi Mothibe, Phikelelani Ngubane, Andile Khathi, Ntethelelo Sibiya. Drug-induced mitochondrial toxicity: Risks of developing glucose handling impairments. Frontiers in Endocrinology. 2023;14. doi:https://doi.org/10.3389/fendo.2023.1123928 

2. Alqahtani T, Deore SL, Kide AA, et al. Mitochondrial dysfunction and oxidative stress in Alzheimer’s disease, and Parkinson’s disease, Huntington’s disease and Amyotrophic Lateral Sclerosis -An updated review. Mitochondrion. 2023;71:83-92. doi:https://doi.org/10.1016/j.mito.2023.05.007 

3. Sultana MA, Hia RA, Akinsiku O, Hegde V. Peripheral Mitochondrial Dysfunction: A Potential Contributor to the Development of Metabolic Disorders and Alzheimer’s Disease. Biology. 2023;12(7):1019. doi:https://doi.org/10.3390/biology12071019 

4. Qin P, Sun Y, Li L. Mitochondrial dysfunction in chronic neuroinflammatory diseases (Review). International Journal of Molecular Medicine. 2024;53(5). doi:https://doi.org/10.3892/ijmm.2024.5371 

5. Gallo G, Speranza Rubattu, Volpe M. Mitochondrial Dysfunction in Heart Failure: From Pathophysiological Mechanisms to Therapeutic Opportunities. International Journal of Molecular Sciences. 2024;25(5):2667-2667. doi:https://doi.org/10.3390/ijms25052667 

6. de Mello AH, Costa AB, Engel JDG, Rezin GT. Mitochondrial dysfunction in obesity. Life Sciences. 2018;192:26-32. doi:https://doi.org/10.1016/j.lfs.2017.11.019 

7. Büttiker P, Weissenberger S, Esch T, et al. Dysfunctional mitochondrial processes contribute to energy perturbations in the brain and neuropsychiatric symptoms. Frontiers in Pharmacology. 2022;13:1095923. doi:https://doi.org/10.3389/fphar.2022.1095923 

8. Hamilton D, Jensen GS. Alternative Therapies In Health And Medicine – A Peer-Reviewed Journal. Alternative-therapies.com. Published 2017. Accessed January 30, 2025. https://www.alternative-therapies.com/abstracts/24042.html

9. Sinha R, Sinha I, Calcagnotto A, et al. Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function. European Journal of Clinical Nutrition. 2018;72(1):105-111. doi:https://doi.org/10.1038/ejcn.2017.132